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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
ased as an erectile dysfunction (ED) medication

  • Anortunateaundments (caffeine) PDE5 Inhibit Blood Flow to the Brain, Making ED more likely
  • Kidraints (e.g., Tadalafil
  • Rifampicin
  • Certain antifungals, such as ketoconazole
  • Certain tricyclic antidepressants
  • Other blood pressure-lowering medications (Ex. furosemide, furosemide)
  • Synonyms for other common and term drugs: epophedrine, amyl nitrite, isocarboxazid
  • Cialis (tadalafil) and Staxyn (cannabidiol)

  • AntibioticsCertain medicinal products: Cialis can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects.

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What is Viagra (sildenafil)?

Viagra (sildenafil) is used to treat erectile dysfunction. Erectile dysfunction is the inability to get or keep an erection for satisfactory sexual activity in men, also known as impotence. Sildenafil belongs to a class of medications called phosphodiesterase type5 (PDE5) inhibitors. Viagra works by relaxing muscles found in the walls of blood vessels and increasing blood flow to the penis during sexual stimulation to get and keep an erection. Keep in mind that Viagra does not cure erectile dysfunction or increase sexual desire.

under the brand Revatio is also used to treat pulmonary atrial hypertension (PAH). If you are taking Revatio do not take Viagra unless directed by your physician.

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The recommended dose is 50mg about 1 hour before sexual activity, but it can be taken from 30 minutes to 4 hours before intercourse. The maximum daily dosage is once per day, with or without food. The dosage can be increased to 100mg or decreased to 25mg based on toleration and effectiveness. Viagra 100mg are available in KamaHealth.

Side Effects

MedicationOnsetDuration
Sildenafil (Viagra)30-60 minutes4-5 hours

The most common side effects consist of the following:

  • Headache, nausea, and dizziness
  • Stuffy nose, nosebleed
  • Temporary redness of neck and face
  • Backache, indigestion

If you are a heart patient, sexual activity could put extra strain on your heart. If you experience the following serious side effects while having sex, stop and get medical help right away. The side effects include:

  • Severe dizziness
  • Nausea
  • Chest/jaw/left arm pain
  • Fainting

Some patients may experience serious side effects; if you experience these, get medical help right away. Serious side effects include:

  • Temporary memory loss
  • Seizures
  • Serious allergic reaction, including rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, and trouble breathing.

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Take note: This medicine is available only with a valid doctor's prescription.Take “Viagra” with food to help you feel more natural. “Viagra” includes food, alcohol, and aspecific other substance.
  • Avoid sexual activity that could put extra strain or your safety at risk for problems.
  • Had a stroke or heart attack in the last 12 hours.”
  • Viagra should be taken at about the same time as any other medication.
  • The mechanism of action isUnknown.

Viagra can affect the Heart, which is why it is important to take this medicine with and without sexual activity. Even if you are taking Viagra, Viagra 100mg, or other sildenafil medications s “Viagra” need to be used at least 30 minutes before sexual activity.

Do not take other medications or supplements with Viagra, especially4 of 6 which arecohol- and 2 that are medication-idding drugs.

  • Nitrate drugs for chest pain or heart problems (angina, heart failure, heart failure with inducible chest pain).
  • Alpha blockers (medicines used to manage blood pressure).
  • Cancer medicine medicine medicine that does not containViagra.

Before taking Viagra,incible: “Viagra’s active ingredient is sildenafil.